Thesis (M.Sc.) - University of Warwick, 1987.
|Statement||Laurie Chi-Kwong Lau.|
Platelet hyperactivity and abnormal CA2+ homeostasis in diabetes mellitus Article (PDF Available) in AJP Heart and Circulatory Physiology (4):H May with 34 Reads How we measure. It is increasingly recognized that platelets are the culprit cells implicated in the propensity to atherothrombosis in the setting of both type 1 and type 2 diabetes mellitus, making the study of. Summary. Diabetes is associated with increased platelet reactivity. Factors that contribute directly to greater platelet reactivity include metabolic abnormalities such as hyperglycemia and hyperlipidemia, both insulin resistance (relative insulin deficiency) and absolute insulin deficiency, as well as associated conditions such as oxidative stress, inflammation, and endothelial by: Platelet abnormalities in diabetes mellitus. Ferreiro JL(1), Gómez-Hospital JA, Angiolillo DJ. Platelets of DM patients are characterised by dysregulation of several signalling pathways leading to intensified adhesion, activation and aggregation. Multiple mechanisms are involved in platelet dysfunction of patients with DM, which can be Cited by:
Such studies have revealed the presence of more than unique proteins in anuclear platelets that are generated by megakaryocytes or have been taken up by endocytosis. The highly dynamic protein content of platelets has been studied by diverse proteomic technologies using resting and activated platelets, and in both health and disease. Diabetes mellitus (DM), characterised by chronic hyperglycaemia, is a rapidly growing worldwide health problem. CD40 ligand (CD40L), a member of the TNF-alpha family, is also expressed on activated platelets in diabetes, Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitus, Am. J. Physiol. Heart Circ. Physiol. Patients with diabetes mellitus have an increased prevalence of vascular disease. Pathologic thrombosis associated with atherosclerotic plaque rupture is a major cause of morbidity and mortality. Platelets are intimately involved in the initiation and propagation of thrombosis. Evidence suggests that platelets from patients with type 2 diabetes have increased reactivity and baseline activation Cited by: IN Halushka and his colleagues reported that platelets from patients with diabetes produced more prostaglandin E-like material upon exposure to adenosine diphosphate, epinephrine, or collagen Cited by:
PLATELET FUNCTION IN DIABETES MELLITUS Relationships to hyperglycaemia, antidiabetic accompany diabetes can adversely influence platelets and vascular endothelial function, which studies of the effect of acute hyperglycaemia on platelet function in patients with DM are sparse Platelet hyperreactivity is a factor which contributes towards increased risk of cardiovascular events in adults with type 2 diabetes (T2DM). However, little is known about platelets’ disturbances among children with type 1 diabetes (T1DM). The aim of the study was to investigate whether platelets’ morphology or function are altered in children with type 1 diabetes, potentially Cited by: 8. Platelets of patients with type 2 diabetes mellitus show abnormal calcium homeostasis. Increased calcium mobilisation from intra-platelet storage pool and higher levels of intracellular free calcium has been reported in patients with diabetes mellitus,17 Intracellular free . HEMATOLOGY CASE STUDIES: PLATELETS OBJECTIVES: After completing this course the participant will be able to: 1. Differentiate among the causes of thrombocythemia. 2. Explain how to determine the platelet count when the count is above the upper reportable range of the analyzer. 3. Estimate the platelet count from the blood smear. Size: KB.